Endocrine Abstracts

Background: Osteopetrosis is a rare chronic bone disease with high bone mineral densitiy due to impaired osteoclast activity or development. Genetic mutations result in severe infantile (autosomal recessive, incidence 1:200,000) and less severe adult forms (autosomal-dominant osteopetrosis/ADO). The incidence is estimated at 1:20,000 for noninfantile forms. In adults osteopetrosis is often asymptomatic with increased risk for bone fracture. Treatment is symptom-based (e.g. cal...

Introduction: We retrospectively evaluated all patients with pituitary tumours treated in our department from 1.1.1997–1.11.2014Patients and methods: 215 patients (124 females: 91 males, mean age 50,9 y.) were treated because of pituitary tumours. All patients underwent basal hormonal analysis and testing in order to check for hormonal activity. Pituitary masses were divided into groups concerning their hormonal status and were further classified ac...

Introduction: We retrospectively evaluated all patients with adrenal tumours treated in our Department from 1.1.1999 to 1.10.2013.Patients and methods: 189 patients (110 females: 79 males, mean age of 57.5 years) were treated because of adrenal tumours. All patients underwent hormonal analysis and testing in order to check for hormonal activity. Tumours were classified according to gender, age at diagnosis, tumour localisation and size, as well as benign...

Background: Ectopic Cushing Syndrom (ECS) represents approximately 12% of all patients with Cushing´s disease. Either ACTH (5–10%), CRH or cortisol is produced uncontrolled from nonpituitary tissue. Half of ECS cases are neuroendocrine lung tumors [carcinoid tumors > small cell lung carcinoma (SCLC)], but ECS is clinically apparent only in 1–5% of SCLC cases. Clinical features vary according to extent and duration of exposure to ACTH/Cortisol excess and in...

Introduction: To reliably assess glomerular filtration is of vital importance if oral antidiabetics are used. We compared the CKD-EPI model, a clinically established calculation model to assess creatinine clearance (CreaClear) with specimens from 24-h urine.Method: Inpatients (university hospital) with diabetes mellitus received a 24-h urine collection (24hClear) or since 2013 calculated CreaClear using CKD-EPI-formula (EPI). From 2014 to 2015 values of ...